Overview

The GRAB (Genome-wide Robust Analysis methods designed for Biobank data) R package is primarily designed to perform GWAS accounting for sample relatedness and population structure. It supports multiple trait types with unified two-step framework. Additionally, the package can be used to:

• Simulate genotype and phenotype data
• Calculate sparse GRM
• Read genotype data from PLINK or BGEN files

Installation

CRAN

Install GRAB from CRAN in your R console:

install.packages("GRAB", dependencies = TRUE)

Conda

Install GRAB in a new Conda environment named grab_env from the conda-forge channel:

conda create -n grab_env -c conda-forge r-grab r-skat r-dbplyr r-tidyr

Docker

Pull the latest GRAB Docker image from Docker Hub:

docker pull geneticanalysisinbiobanks/grab:latest

License

GRAB is distributed under a GPL license.

Contact

If you have any questions about GRAB, please contact miaolin@pku.edu.cn.